According to the Egyptian Railways Authority, the accident happened when a passenger train ignored a stop signal entering Kaliub station. This led to the derailment of the locomotive and the first wagon. Pictures from the scene of the accident showed that a crane was brought there to recover the fallen parts of the train.

Fatal accidents are common in Egypt, both on the rails and on the roads. In April 2021, Minister of Transport Kamel el-Wasir fired the head of the railway authority shortly after a train accident that killed 23 people.